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Background: Globally 憃ral cancer� is the sixth most common cause of cancer-related death. Oral cancer accounts for approximately 30-40% of all cancers in India. The present study was conducted to assess biochemical parameters in newly diagnosed oral cancer. Methods: The present study was conducted to assess biochemical parameters in newly diagnosed oral squamous cell carcinoma. The study was conducted at GSVM Medical College, Kanpur among 196 newly diagnosed patients with oral squamous cell carcinoma and 196 healthy individuals. Serum samples from the participants were collected. The data were expressed as mean盨D. Values of p<0.001 were considered significant. Results: The present study was conducted to assess biochemical parameters in newly diagnosed oral cancer. The study was conducted at GSVM Medical College, Kanpur among 196 newly diagnosed patients with oral cancer and 196 healthy individuals. The levels of Random Blood Sugar, Serum Total Bilirubin, Direct Bilirubin, Indirect Bilirubin, Glutamic-oxalacetic transaminase (SGOT), glutamic-pyruvic transaminase (SGPT), Serum Protein, Serum Albumin, Serum Creatinine, Serum Sodium, Serum Potassium were increased in cases as compared to controls. The p-value was non-significant for all the biochemical parameters. Conclusion: The present study concluded that the levels of Random Blood Sugar, Serum Total Bilirubin, Direct Bilirubin, Indirect Bilirubin, SGOT, SGPT, Serum Protein, Serum Albumin, Serum Creatinine, Serum Sodium, Serum Potassium were increased in cases as compared to healthy controls.
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Background: Serum pregnancy-associated plasma protein-A (PAPP-A) levels fluctuate in continuation with the pregnancy and thus become an important standalone marker in monitoring the adverse outcomes that may occur in pregnancy.Methods: A prospective observational study was conducted in the department of obstetrics and gynaecology. A total of 240 pregnant women in their first trimester were included in the study. Serum PAPP-A levels were measured at 11-13+6week of gestation and were evaluated with respect to the feto-maternal outcome. The data was entered in MS excel spreadsheet and analysis was done using Statistical Package for Social Sciences (SPSS) version 21.0.Results: The mean age of the study population was 27 years. Among the maternal pregnancy parameters, PIH, pre-term labor and Emergency LSCS were significantly associated with low (<0.5 MoM) Serum PAPP-A levels, P<0.05. All the fetal outcome measures: IUGR, IUD, low birth weight, SGA babies, prematurity and NICU admissions, were significantly associated with low (<0.5 MoM) Serum PAPP-A levels, p <0.05.Conclusions: Serum PAPP-A in the early pregnancy showed significant correlation with feto-maternal outcome. Thus, it has the potential to be used as a prognostic factor and in the management of adverse outcomes by increasing surveillance for pregnant women with high-risk factors.
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Antheraea assamensis Helfer, popularly known as Muga silkworm, the golden silk producer of Northeast India, is economically important and unique among the Saturniid silkworms. Muga silkworm is said to exhibit three semi-domesticated morphs i.e. green, blue, orange and one wild morph. In this study, the genetic diversity and phylogeny among the morphs of Muga silkworm collected from various geographical locations of Northeast India were investigated using RAPD and internal transcribed spacer DNA1 (ITS1) sequences. Thirty random primers generated 192 discrete bands; 123 of them were polymorphic (64.062%). The average amplicon per primer was found to be 6.4. In RAPD analysis, a wide range of genetic distance i.e. 0.0544-0.6228 was observed among the morphs. In the ITS1 sequence analysis, 35.35% of polymorphism and a range of genetic distance from 0.0024 to 0.2349 were observed. The phylogenetic trees based on RAPD and ITS1 sequences comprised of two major clades. The first clade comprised of the semi-domesticated morphs while the second clade included the wild morphs of different geographical origin. The information generated in this study can be used for conservation of the Muga silkworm through effective breeding programs
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Background: Cardiovascular diseases, the leading causes of death in the world are rising rapidly in low- and middle-income countries. Our aim was to fine out the correlation between High-Sensitive C–reactive Protein with Lipid Profile Parameter. Methods: The strong and statistically significant positive correlation in between High-Sensitive C–reactive Protein (hsCRP) and Total Cholesterol with (p<0.016). Results: Statistically significant positive correlation between High-Sensitive C–reactive Protein and Triglycerides (p<0.001). LDL-C also showed a statistically significant positive correlation with High-Sensitive C–reactive Protein (p<0.03). HDL-C also showed a statistically not significant negative correlation with High-Sensitive C–reactive Protein (p<0.32). Conclusion: The patients with dyslipidemia for elevated blood hsCRP levels may be done to identify those patients with an increased risk stratification of atherosclerosis. Also this suggests that there may be a role for anti -inflammatory agents along with statins in treatment of dyslipidemia.
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INTRODUCTION: Tobacco use among school children is becoming a serious problem indeveloping countries. The early age of initiation underscores the urgent need to intervene and protect this vulnerable group from becoming victims of this addiction. AIM: To assess the knowledge, attitudes, and practices about tobacco use among 13‑15 year old school children of Bangalore City. MATERIALS AND METHODS: A cross‑sectional study was designed and data on tobacco usage was collected from 1288 students aged 13‑15 years studying in six government and private schools of Bangalore using a self‑administered closed ended questionnaire. Data was analyzed using SPSS 15.0 and descriptive statistics was applied. Chi‑square tests were used to determine the significant differences in the variables of interest. RESULTS: Out of 1288 children, 1281 (99.5%) children had heard about tobacco and 1162 (90.2%) students knew the harmful effects of tobacco. Only 28 (2.2%) had used tobacco products. Peer pressure was the main reason for tobacco use among children and age was not a barrier in buying tobacco products. Television (58%) was the main source of information for tobacco products followed by newspapers (26%) and movies (16%). CONCLUSION: It is encouraging to find that majority of the 13‑15 year old children surveyed in the present study did not use tobacco and were aware of the health risks associated with tobacco use. This calls for the school authorities to be included in stricter implementation and monitoring of the implementation of legislation. Regular and systematic education programs catering to teachers, children, and also their parents should be undertaken.
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Chest pain frightens many people into thinking that they might be having a heart attack. There are many causes of chest pain, few of which are life-threatening. One of the causes of chest pain is vasospasms, which is transient in nature and prolonged episodes can lead to tissue necrosis. Therefore, a prompt diagnosis and treatment is vital to the management. We are reporting a case of a young female presented with chest pain with no history of drug use, previous episodes, palpitations, and hypertension being her only risk factor found to have elevated Troponin I and was diagnosed with non-ST elevation myocardial infarction (NSTEMI), later found to have coronary vasospasm.